Genetics & Genomics
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Are endocannabinoid type 1 receptor gene (CNR1) polymorphisms associated with obesity and metabolic syndrome in postmenopausal Polish women?
Objective: The aim of this study was to determine whether genetic variation at the cannabinoid receptor-1 (CNR1) locus could have an effect on adiposity, fat distribution and obesity-related metabo…
Received 05 November 2009 01:29 UTC; Posted 06 November 2009
Posted to: Genetics & Genomics
9aaTADs mimic DNA to interact with a pseudo-DNA Binding Domain KIX of Med15 (Molecular Chameleons)
The KIX-domain of Gal11/MED15 was shown to interact with short transactivation domain of Pdr1 and Oaf1 (12 and 9 amino acids respectively) annotated to 9aaTAD family. Reported NMR data revealed a s…
Received 03 November 2009 21:11 UTC; Posted 05 November 2009
Posted to: Genetics & Genomics
Common Transactivation Motif 9aaTAD recruits multiple general co-activators TAF9, MED15, CBP and p300
More than 2000 transcription factors are involved in the human gene regulation to provide cellular function and development. Transactivation domain, TAD, mediates the interaction of transcription f…
Received 03 November 2009 12:30 UTC; Posted 05 November 2009
Posted to: Genetics & Genomics
MicroDNAs and Transcriptional Regulation
Synthetic "microDNAs (MIDs)"is a new class of ~ 20-25 nucleotide-long DNAs capable of repressing the activity of the target gene at the level of transcription by mechanisms that have not …
Received 04 November 2009 08:33 UTC; Posted 04 November 2009
Posted to: Cancer, Genetics & Genomics, Molecular Cell Biology
No evidence for a recent genetic bottleneck in the endangered Sheko cattle breed (African Bos taurus) revealed by microsatellite analysis
Sheko is African taurine cattle, valued for its milk yield, adaptation to humid tsetse infested environment and trypanotolerance. We used 30 microsatellite markers in analyzing 30 DNA samples. We f…
Received 30 October 2009 14:01 UTC; Posted 03 November 2009
Posted to: Genetics & Genomics
Design of a dynamic model of genes with multiple autonomous regulatory modules by evolution in silico
A new approach to design a dynamic model of genes with multiple autonomous regulatory modules by evolution in silico is proposed. The approach is based on Genetic Algorithms, with new crossover ope…
Received 29 October 2009 00:50 UTC; Posted 29 October 2009
Posted to: Biotechnology, Developmental Biology, Genetics & Genomics, Bioinformatics, Evolutionary Biology
The Role of Neuregulin 1 in Schizophrenia: A Bioinformatics Approach
Context: Notwithstanding the great number of studies on the etiology and pathophysiology of schizophrenia, both issues remain far from being fully understood. Schizophrenia seems to be related to…
Received 27 October 2009 21:54 UTC; Posted 28 October 2009
Posted to: Genetics & Genomics, Neuroscience, Bioinformatics
BRAGOMAP – a new Perl script for high throughoutput blast results analysis including GO and MapMan automatic annotations
Analyzing of sequences similarities is the first and most important method used to find out the function of unknown nucleotides. Searching of homologs should be done carefully not to loose any impo…
Received 25 October 2009 19:49 UTC; Posted 26 October 2009
Posted to: Genetics & Genomics, Bioinformatics, Plant Biology
Genes of the serotonergic and dopaminergic pathways and their interaction affect the expression of Behavioural and Psychological Symptoms in Dementia (BPSD).
Although there is evidence for the involvement of genes of serotonergic and dopaminergic systems in the manifestation of the Behavioural and Psychological Symptoms in Dementia (BPSD), genetic assoc…
Received 23 October 2009 20:37 UTC; Posted 26 October 2009
Posted to: Genetics & Genomics, Neuroscience
The cultural epigenetics of psychopathology: The missing heritability of complex diseases found?
We extend a cognitive paradigm for gene expression to the epigenetic epidemiology of mental disorders, recognizing the fundamental role that culture plays in human biology as another heritage mecha…
Received 22 October 2009 17:08 UTC; Posted 23 October 2009
Posted to: Developmental Biology, Genetics & Genomics, Neuroscience
