Pharmacology
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In vitro synergistic anti-prion effect of cholesterol ester modulators
Background. Our studies on the role of cholesterol in prion infection/replication showed that brains and peripheral cells of sheep susceptible to or suffering from Scrapie were characterized by an …
Received 21 October 2009 13:06 UTC; Posted 21 October 2009
Posted to: Microbiology, Neuroscience, Pharmacology
Performance of the ALOGPS 2.1 program for octanol-water partition coefficient prediction with organic chemicals on the Canadian Domestic Substances List
The KOWWIN and ALOGPS octanol-water partition coefficient (Kow) estimation software programs were compared for their capacity to accurately predict log Kow values of 1596 organic compounds on t…
Received 21 October 2009 04:30 UTC; Posted 21 October 2009
Posted to: Chemistry, Pharmacology, Earth & Environment
Polyelectrolyte multilayer assembly bearing ketoprofen for transdermal delivery
A novel microencapsulation technology based on layer-by-layer assembly has been extensively studied and used for controlled delivery of drug microcrystal having poor aqueous solubility and low bioa…
Received 11 October 2009 07:28 UTC; Posted 12 October 2009
Posted to: Pharmacology
A novel strategy for the targeted analysis of protein and peptide metabolites
The detection and quantitation of exogenously administered biological macromolecules (e.g. vaccines, peptide and protein therapeutics) and their metabolites is frequently complicated by the presenc…
Received 29 September 2009 07:56 UTC; Posted 29 September 2009
Posted to: Biotechnology, Immunology, Pharmacology
Prediction of Evolutionarily important catalytic amino acid of Mycobacterium tuberculosis O-Succinylbenzoate synthase through in silico mutational analysis
The emergence of tuberculosis resistant to multiple, first- and second-line antibiotics poses challenges to a global control strategy that relies on standard drug treatment regimens. The high drug-...
Received 17 September 2009 10:51 UTC; Posted 18 September 2009
Posted to: Biotechnology, Microbiology, Pharmacology, Bioinformatics
Repurposing of Meropenem and Nadifloxacin for Treatment of Burn Patients?
The escalating number of multidrug resistant pathogens has demanded the swift development of new and potent antibiotics (ref. 2). Metallo-β-lactamases (MBLs) continue to evolve, rendering the …
Received 14 September 2009 20:46 UTC; Posted 15 September 2009
Posted to: Pharmacology
Choice reveals that rats are majoritarily resilient to cocaine addiction
Assessing the relative reward value of cocaine and how it changes with repeated use represents a long-standing goal in addiction research. Surprisingly, recent experimental research in rats – the m…
Received 09 September 2009 08:32 UTC; Posted 09 September 2009
Posted to: Neuroscience, Pharmacology
Polymerase-endonuclease amplification reaction for large-scale enzymatic production of antisense oligonucleotide
Synthetic oligonucleotides are contaminated with highly homologous failure sequences. Oligonucleotide synthesis is difficult to scale up because it requires expensive equipments, hazardous chemical…
Received 02 September 2009 04:00 UTC; Posted 02 September 2009
Posted to: Biotechnology, Chemistry, Pharmacology
Preconditioning of Nanofibers with Embryonic Stem Cells Is Nephroprotective
We report that "preconditioning" of self-assembling nanofibers with embryonic stem cells (ESC) can be used to effectively deliver paracrine/endocrine factors from ESCs to the target tissu…
Received 26 August 2009 19:07 UTC; Posted 27 August 2009
Posted to: Biotechnology, Pharmacology
Discovery of multiple lead compounds as M2 inhibitors through the focused screening of a small primary amine library.
The discovery of new anti-influenza drugs is urgent, particularly considering the recent threat of swine flu. In this study, the influenza virus M2 protein was expressed in HEK293 cells and shown t…
Received 26 August 2009 10:54 UTC; Posted 26 August 2009
Posted to: Chemistry, Pharmacology
